In this article the validity of transferring the Principle of Double Effect from the just war tradition to the domain of business is critically reviewed. If a case can be built for sufficient analogies between war and business, the principle of double effect can legitimately be transferred from war to business. If, on the other hand it can be shown that there are aspects in which business differs substantially from just war, then the transfer to business of a principle developed (...) within the context of war becomes more problematic. After exploring the nature of arguments of analogy and fallacious arguments of weak analogy some important disanalogies between war and business are highlighted. Given these disanalogies it is then contended that the just war background of the Principle of Double Effect had some bearing on both the content and manner of application of the Principle of Double Effect. Finally it is argued that these disanalogies require some revisions to the Principle of Double Effect with regard to both its content and its manner of application before it can be applied meaningfully to foreseeable negative side-effects of business. S. Afr. J. Philos. Vol.22(3) 2003: 236–246. (shrink)

Motor processes cannot be modeled by a single (unified) model. Instead, a number of models at different levels of description are needed. The concepts of control and control variable only make sense at the functional level. A clear distinction must be made between external models and internal models. General Systems Theory provides the framework for a proper treatment of these issues.

A gas in a box is perhaps the most important model system studied in thermodynamics and statistical mechanics. Usually, studies focus on the gas, whereas the box merely serves as an idealized confinement. The present article focuses on the box as the central object and develops a thermodynamic theory by treating the geometric degrees of freedom of the box as the degrees of freedom of a thermodynamic system. Applying standard mathematical methods to the thermody- namics of an empty box allows (...) equations with the same structure as those of cosmology and classical and quantum mechanics to be derived. The simple model system of an empty box is shown to have interesting connections to classical mechanics, special relativity, and quantum field theory. (shrink)

Alpha‐fetoprotein (AFP)AFP, alpha‐fetoprotein; T3R, thyroid hormone (triiodothyronine) receptor; RAR, retionic acid receptor; erbA, putative thyroid hormone receptor proto‐oncogene products; VDR, vitamin D receptor; MR, mineralocorticoid receptor; GR, glucocorticoid receptor; PR, progesterone receptor; AR, androgen receptor; HRE, hormone response element on DNA; RXR, retionic‐X‐receptor; RAP, receptor auxiliary (accessory) proteins; E, estrogen. is a tumor‐associated fetal marker, associated both with tumor growth and with birth defects. AFP, whose precise function is unknown, has been classified as belonging to a protein superfamily together with (...) albumin and vitamin D‐binding (Gc) protein. AFP has been shown to bind various ligands in vitro including fatty acids, estrogens, thyroid hormones and retinoic acids. The steroid/thyroid nuclear receptor superfamily of proteins has recently become a major focus of biomedical investigation regarding regulation of gene expression. These receptors are thought to bind to DNA‐hormone response elements (HRE) that affect growth, development, differentiation, reproduction and homeostasis. The HREs are known to share DNA sequences with the various members of the nuclear receptor superfamily. In the present report, the possibility of a leucine‐zipper dimerization (heptad) motif in the carboxy‐terminal third domain of both rodent and human AFP is postulated. The presence of nine such hydrophobic repeats in the third domain of the AFP molecule mimics the heptad dimerization repeats found in the retinoic acid, thyroid, e‐erbA and other members of the nuclear receptor superfamily. Computer analysis revealed that the most conservative matching occurred between AFP and the retinoic acid class of receptors. However, other superfamily members displayed 40–60% homology with 5 of 9 AFP heptads. These findings could provide a possible mechanism for explaining the growth‐regulatory properties (both inhibition and enhancement) that have been ascribed to AFP in the last decade. (shrink)

In a broadcast talk delivered in 1956, the late J. L. Austin began by outlining to his listeners his now well-known concept of ‘the performative utterance and its infelicities’; and at the end of that first section of his talk he made this comment: ‘That equips us, we may suppose, with two shining new tools to crack the crib of reality maybe. It also equips us – it always does – with two shining new skids under our metaphysical feet’. In (...) this talk I intend to illustrate a particular respect in which, in moral philosophy, the partial pessimism of Austin's comment has proved abundantly justified. I shall try to show how in this field one shining new tool has led in fact to the skidding of moral philosophers' feet – how one bright idea has led some influential theorists off in the wrong direction, and the rest of us back in the end, with rather little gained, to a position not far from that of our predecessors of about a hundred years ago. This dismal story, I should in justice make clear at the outset, is not that of the whole of moral philosophy, not even of moral philosophy in English; I shall be tracing only one out of several concurrent lines of thought, but the line which I shall trace will be, I think, readily recognised as having been, and perhaps as still being, more conspicuous than most. (shrink)

Professor Frankena mentions me as one of the participants in what he calls the Movement in moral philosophy, and I think he is right; I was so moving, or being moved along among others, ten years or so ago, and I think I find myself still inclined to so move, while recognising with regret, when I come to look back at it, that, as he courteously observes, “what such writers say is not as clear as one would like.” I embark (...) on commenting upon his lectures with considerable trepidation, however, for the reason that, while his own writing surely is as clear as one could reasonably hope for, I have had great difficulty in figuring out what exactly it is in the Movement that he substantially dissents from, and have the lurking suspicion that there may be something that I have just failed to see. Tentatively, though, I tend to think that the root of my difficulty has been that he offers, in opposition to the Movement, an account of these matters that is really, in the end, not intelligible; and my main task in this commentative piece will be to try to explain why I think that. (shrink)

The question that I want to debate a little in this paper could be put in this way: what, and how much, empirical information is required for, or relevant to, moral philosophy? That question may well strike one as somewhat vague and woolly. Rightly so. What is needed to get rather clearer about its answer or possible answers is chiefly, I believe, to get clearer about its sense.

Philosophy and philosophical workers play very important roles in the socialist society of the People's Republic of China. No longer is philosophy treated as an object of speculation; nor is it regarded as merely a method of applying theory. It is now considered to be a process of learning from the practical experience of the masses, a process of enriching the concrete life of the people, and a process of solving specific problems in remaking society and changing the world. Briefly (...) speaking, philosophy plays the important role of eliminating alienation and the possibility of alienation among men. On this basis, philosophical workers, like other intellectuals, are urged to unite with and learn from the masses — the industrial workers and the peasants. Many writings have focused on this Maoist point, which is exemplified in this issue by Kuan Feng's article. From this point of view, traditional philosophy, which fails to eliminate alienation and which in fact tends to create and justify alienation as defined by Marxist and Maoist ideology, is subjected to severe criticism. (shrink)